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Fences and pickets model of plasma membrane structure : ウィキペディア英語版 | Fences and pickets model of plasma membrane structure The Fences and pickets model of plasma membrane is a concept of cell membrane structure suggesting that the fluid plasma membrane is compartmentalized by actin-based membrane-skeleton “fences” and anchored transmembrane protein “pickets”. This model differs from older cell membrane structure concepts such as the Singer-Nicolson fluid mosaic model and the Saffman-Delbrück two-dimensional continuum fluid model that view the membrane as more or less homogeneous. The fences and pickets model was proposed to explain observations of molecular traffic made due to recent advances in single molecule tracking techniques. ==Membrane skeleton fence model== The actin-based membrane skeleton (MSK) meshwork is directly situated on the cytoplasmic surface of the plasma membrane. Membrane skeleton fence, or membrane skeleton corralling model, suggests that this meshwork is likely to partition the plasma membrane into many small compartments with regard to the lateral diffusion of membrane molecules. Cytoplasmic domains collide with the actin-based membrane skeleton which induces temporary confinement or corralling of transmembrane (TM) proteins in the membrane skeleton mesh. TM proteins are capable to hop between adjacent compartments when the distance between the meshwork and the membrane becomes large enough, or when the meshwork temporarily and locally dissociates. Cytoplasmic molecules located on the inner surface of the plasma membrane also exhibit confinement within actin-based compartments.
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